ANTIBODIES TO PHOSPHOLIPIDS AND ISCHEMIC DISORDERS OF CEREBRAL-CIRCULATION IN YOUNG AGE

Antibodies to phospholipids (APL) were studied in 97 patients which ha d ischemic stroke in young age (up to 46 years). These antibodies (Abs ) were found in 25 patients (26%): Abs to car; diolipin - in 15 patien ts (60%), Abs to lupoid anticoagulant in 18 from 24 patients (75%), Ab s to phosphatidylethanolamine - in 4 from 13 patients (31%). Disorders of cerebral circulation (DCC) usually began at the age of 14-45 years and were characterized by ischemic strokes and by transitory DCC. The re was no correlation between the occlusion of extracranial arteries a nd their hemodynamic significant stenosis. There was occlusion of intr acranial arteries in 7 from 12 patients (58%). Other risk factors of t he stroke development were also found in 19 patients (76%) together wi th Abs to phopholipids. Other manifestations of antiphospholipid syndr ome (APLS) were observed In 68% of the patients : miscarriage of pregn ancy (63%), thrombosis of peripheric veins (16%), thrombocytopenia (32 %), ischemic heart disease (28%). Comparison of APL+ and APL- patients revealed that transitory DCC, occlusion of intracranial arteries, int act extracranial arteries, widening or condensation of the cardial val ves on echo-EGG, abortions, increase of ESR were significantly more fr equently observed in the former group. For confirmation of APLS diagno sis it was necessary to study simultaneously Abs to cardiolipin and lu poid anticoagulant. Prophylaxis of repeated DCC in APLS included admin istration of both aspirin and anticoagulants of indirect action.