PECULIARITIES OF CLINICAL COURSE OF NEPHR ITIS IN PATIENTS WITH CRYOGLOBULINEMIA

Cryoglobulins were measured spectrophotometrically in the sera of 40 p atients with renal diseases. 18 of them had chronic glomerulonephritis , 14 lupus nephritis and 8 nephritis. 20 patients with high concentrat ion of cryoglobulins (100-600 mu g/ml) exhibited high incidence of nep hrotic syndrome (80%), arterial hypertension (90%), creatininemia (70% ) and, respectively, 25, 25 and 15% of patients free of cryoglobulinem ia. There was a correlation between cryoglobulins level and creatinine mia (r = 0.468), proteinuria (r = 0.478), ESR (r = 0,393), systolic an d dyastolic arterial pressure (r = 0.393 and r = 342, respectively). A n inverse relation existed with serum albumins (r = -0.526). Progressi on of renal failure was associated with high cryoglobulinemia. In decl ine of cryoglobulins content there was clinical improvement, lowering or normalization of blood creatinin levels.