EFFICACY OF SULODEXIDE, LOW-MOLECULAR HEP ARIN, IN THERAPY OF DIABETIC NEPHROPATHY

A novel pathogenetic approach to treatment of diabetic nephropathy (DN ) as a severe complication of diabetes mellitus is aimed at inhibiting DN progression or its involution by means of reestablishment of hepar ansulfate synthesis by glycosaminoglycane drug. In the study of 9 pati ents with microalbuminuria and 9 with proteinuria this drug was low-mo lecular heparin - sulodexide (Alfa-Wasserman, Italy). The treatment co urse of 3 weeks resulted in albuminuria fall in 89% of patients. In pa tients with microalbuminuria protein excretion returned to normal valu es in a week of treatment. This effect was persistent after the drug d iscontinuation. This was not so for protein excretion in proteinuria p atients which became low after 3 weeks of treatment, but the effect wa s not long-lasting. The authors believe that glycosaminoglycanes hold great promise in DN, especially at early stages of renal diabetic affe ction.