Severe pulmonary hypertensive vascular disease in two newborns with aneurysmal vein of Galen

Arteriovenous malformation of the vein of Galen (AVG) is a rare entity in t he newborn with a high morbidity and mortality. We present two cases of fat al AVG with persistent pulmonary hypertension of the newborn and significan t pulmonary hypertension documented by autopsy histopathology. The pathophy siology is reviewed and a proposed mechanism of the association between AVG and pulmonary hypertension is discussed.