Protein kinase c isoforms as therapeutic targets in nervous system diseasestates

Authors
Citation
F. Battaini, Protein kinase c isoforms as therapeutic targets in nervous system diseasestates, PHARMAC RES, 44(5), 2001, pp. 353-361
Citations number
87
Categorie Soggetti
Pharmacology & Toxicology
Journal title
PHARMACOLOGICAL RESEARCH
ISSN journal
10436618 → ACNP
Volume
44
Issue
5
Year of publication
2001
Pages
353 - 361
Database
ISI
SICI code
1043-6618(200111)44:5<353:PKCIAT>2.0.ZU;2-D
Abstract
Neuronal tissues display high levels of protein kinase C (PKC) activity and isoform expression. The activation of this enzymatic system is important i n the control of short and long term brain functions (ion channel regulatio n, receptor modulation, neurotransmitter release, synaptic potentiation/dep ression, neuronal survival) that are related to diverse brain pathologies. This review will describe recent developments in PKC regulation and changes in levels, isoforms and activation in acute and chronic neurodegenerative pathologies as well as in affective and psychic disorders. The recent avail ability of isoform selective inhibitors and activators may help to understa nd better the relevance of PKC in central nervous system (CNS) physiology a nd pathology and to identify new and safer pharmacologic strategies to be t ested in different disease states. (C) 2001 Academic Press.