RNA-binding proteins and circadian rhythms in Arabidopsis thaliana

Authors
Citation
D. Staiger, RNA-binding proteins and circadian rhythms in Arabidopsis thaliana, PHI T ROY B, 356(1415), 2001, pp. 1755-1759
Citations number
54
Categorie Soggetti
Multidisciplinary,"Experimental Biology
Journal title
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES
ISSN journal
09628436 → ACNP
Volume
356
Issue
1415
Year of publication
2001
Pages
1755 - 1759
Database
ISI
SICI code
0962-8436(20011129)356:1415<1755:RPACRI>2.0.ZU;2-R
Abstract
An Arabidopsis transcript preferentially expressed at the end of the daily light period codes for the RNA-binding protein AtGRP7. A reverse genetic ap proach in Arabidopsis thaliana has revealed its role in the generation of c ircadian rhythmicity: AtGRP7 is part of a negative feedback loop through wh ich it influences the oscillations of its own transcript. Biochemical and g enetic experiments indicate a mechanism for this autoregulatury circuit: At grp7 gene transcription is rhythmically activated by the circadian clock du ring the day. The AtGPR7 protein accumulates with a certain delay and repre sses further accumulation of its transcript, presumably at the post-transcr iptional level. In this respect, the AtGRP7 feedback loop differs from know n circadian oscillators in the fruitfly Drosophila and mammals based on osc illating clock proteins that repress transcription of their own genes with a 24 h rhythm. It is proposed that the AtGRP7 feedback loop may act within an output pathway from the Arabidopsis clock.