SYNTHESIS OF POLYAMIDE NUCLEIC-ACIDS (PNAS), PNA DNA-CHIMERAS AND PHOSPHONIC ESTER NUCLEIC-ACIDS (PHONAS)/

The synthesis of polyamide nucleic acids (PNAs) and derivatives thereo f by different synthetic routes is described. The first strategy makes use of 9-Fluorenylmethoxycarbonyl (Fmoc)/monomethoxytrityl (Mmt) prot ected building blocks, whereas the second approach involves the use of Mmt/acyl protected monomers, which allows the preparation of PNA/DNA chimera. Additionally, a block coupling strategy is presented for the synthesis of novel phosphonic ester nucleic acids (PHONAs).