ANTIVIRAL ACTIVITY OF ANTISENSE OLIGONUCLEOTIDES AGAINST VARIOUS TARGETS OF HERPES-SIMPLEX VIRUS-I (HSV1) AND COXSACKIEVIRUS B3 (CVB3) GENOME

Authors
BIRCHHIRSCHFELD E KNORRE CM STELZNER A SCHMIDTKE M
Citation
E. Birchhirschfeld et al., ANTIVIRAL ACTIVITY OF ANTISENSE OLIGONUCLEOTIDES AGAINST VARIOUS TARGETS OF HERPES-SIMPLEX VIRUS-I (HSV1) AND COXSACKIEVIRUS B3 (CVB3) GENOME, Nucleosides & nucleotides, 16(5-6), 1997, pp. 623-628
Citations number
22
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
16
Issue
5-6
Year of publication
1997
Pages
623 - 628
Database
ISI
SICI code
0732-8311(1997)16:5-6<623:AAOAOA>2.0.ZU;2-P
Abstract
The influence of chemical modification on the antiviral activity of ol igonucleotides was studied on Green monkey kidney cells (GMK) using a known antisense oligodeoxynucleotide (AS-ODN) directed against the IE- 110 gene of HSV1. The highest antiviral activity was observed with ODN s carrying exclusively phosphothioate internucleotide linkages. CVB3-s pecific ODNs of this type were synthesized and successfully tested for antiviral activity on HeLa cells.