SYNTHESIS AND BIOLOGICAL-ACTIVITY OF NEW SUGAR MODIFIED 2',5'-OLIGOADENYLATE TRIMERS

Authors
KVASYUK EI KULAK TI TKACHENKO OV SENTYUREVA SL MIKHAILOPULO IA SUHADOLNIK RJ HENDERSON EE HORVATH SE GUAN MX PFLEIDERER W
Citation
Ei. Kvasyuk et al., SYNTHESIS AND BIOLOGICAL-ACTIVITY OF NEW SUGAR MODIFIED 2',5'-OLIGOADENYLATE TRIMERS, Nucleosides & nucleotides, 16(5-6), 1997, pp. 773-776
Citations number
26
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
16
Issue
5-6
Year of publication
1997
Pages
773 - 776
Database
ISI
SICI code
0732-8311(1997)16:5-6<773:SABONS>2.0.ZU;2-K
Abstract
New 2',5'-oligonucleotide trimers containing 2',3'-dideoxy-3'-fluoro d erivatives of adenosine at the 2'-terminal end of oligomers have been synthesized. Some of the synthesized trimers showed biological inhibit ions of HIV-1 reverse transcriptase and HIV-1 induced syncytia formati on.