ANTIPRURITIC EFFECT OF FLAVONOL AND 1,4-NAPHTHOQUINONE DERIVATIVES FROM IMPATIENS-BALSAMINA L

Authors
ISHIGURO K OKU H
Citation
K. Ishiguro et H. Oku, ANTIPRURITIC EFFECT OF FLAVONOL AND 1,4-NAPHTHOQUINONE DERIVATIVES FROM IMPATIENS-BALSAMINA L, PTR. Phytotherapy research, 11(5), 1997, pp. 343-347
Citations number
15
Categorie Soggetti
Chemistry Medicinal","Pharmacology & Pharmacy
Journal title
PTR. Phytotherapy research → ACNP
ISSN journal
0951418X
Volume
11
Issue
5
Year of publication
1997
Pages
343 - 347
Database
ISI
SICI code
0951-418X(1997)11:5<343:AEOFA1>2.0.ZU;2-0
Abstract
To investigate the effect of antipruritic agents, we developed an anim al model to allow quantitative estimation of itching. Dextran T40 and compound 48/80, agents which cause histamine release, significantly in duced scratching behaviour in mice. A 35% ethanol extract (IB) of whit e petals of Impatiens balsamina L. significantly inhibited the scratch ing behaviour in this model, Kaempferol, quercetin and 1,4-naphthoquin one derivatives in IB were demonstrated to show antipruritic effects. (C) 1997 by John Wiley & Sons, Ltd.