The end of the 20th century saw the realization of a goal that was previous
ly only dreamed about: the near elimination of many deadly infectious disea
ses through universal vaccination. As one disease after another has been dr
iven from memory it is vaccination programs themselves that have come to oc
cupy the public's mind. With increased scrutiny comes the promise that vacc
ines will become even safer, but there is also the threat that ill-founded
concerns will result in reduced immunization rates, and diseases will resur
ge. This article reviews scientific data relating to current vaccine safety
concerns.