Supercritical fluids-assisted micronization techniques. Low-impact routes for particle production

Micronized powders are of interest in many industrial fields, pharmaceutica ls, catalysts, pigments, and biopolymers, for example, are some categories of products that can be used as micro-sized particles. Traditional techniqu es used to produce micronic powders are based on high-temperature reactions that require high energies, on jet milling that is characterized by low ef ficiencies and mechanical stress, and on liquid solvents precipitation that has a poor control on particle size and can pollute the product. Generally , the control of the powder size and the span of its distribution are still very approximate. In the last few years. several supercritical fluids-based techniques have b een proposed for the production of micronic and nanometric particles. These processes try to take advantage of some specific properties of gases at su percritical conditions such as enhanced solubilization power and its modula tion. large diffusivities, solventless or organic solvent reduced operation , and the connected possibility of controlling powder size and distribution . Techniques like the rapid expansion of supercritical solutions (RESS), su percritical antisolvent precipitation (SAS), particle generation from gas-s aturated solutions (PGSS), and new atomization processes have been critical ly reviewed in this work.