Polymorphic variants of the renin-angiotensin system genes in the polymetabolic syndrome and non-insulin-dependent diabetes mellitus

Polymorphisms of the genes for angiotensin-converting enzyme (ACE) and angi otensinogen, the proteins of the renin-angiotensin system (RAS), were teste d for association with the polymetabolic syndrome (PMS) and non-insulin-dep endent diabetes mellitus (NIDDM) in the Moscow population. The insertional (I) allele and the II genotype of the ACE gene proved to be associated with PMS. A significant difference in allele and genotype frequency distributio ns of the (CA),, microsatellite of the 3'-untranslated exon of the angioten sinogen gene was revealed between randomly sampled individuals and patients with PMS and IDDM from the Moscow population.