Podophyllin, a crude plant extract with low efficacy, high toxicity, and a
serious mutagenicity profile does not comply with the WHO guidelines for pl
ant derived treatments and should be removed from clinical treatment protoc
ols. Home treatment with pharmaceutical products based on podophyllotoxin-t
he purified, standardised active antiwart ingredient of podophyllin-represe
nts safe and effective first line therapy for patients with anogenital wart
s.