The interpeduncular cistern is a difficult region to approach through conve
ntional methods due to its deep location and important adjacent neurovascul
ar structures. Therefore, it is usually difficult to expose the region suff
iciently. Technical problems associated with various surgical approaches ha
ve led to emergence of combined approaches and their modifications (i.e., t
he removal of the zygomatic arch). In addition, a frontotemporal craniotomy
is reported to provide a wide exposure of the anterior temporal base, thus
allowing oblique access to the interpeduncular cistern with minimal brain
retraction. This study describes clinicians' experience and the surgical re
sults of 24 patients who underwent a zygomatic anterior subtemporal approac
h.