An enantioselective synthesis of (R)-4-piperidinylglycine

Authors
Shieh, WC Xue, S Reel, N Wu, R Fitt, J Repic, O
Citation
Wc. Shieh et al., An enantioselective synthesis of (R)-4-piperidinylglycine, TETRAHEDR-A, 12(17), 2001, pp. 2421-2425
Citations number
11
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON-ASYMMETRY
ISSN journal
09574166 → ACNP
Volume
12
Issue
17
Year of publication
2001
Pages
2421 - 2425
Database
ISI
SICI code
0957-4166(20010928)12:17<2421:AESO(>2.0.ZU;2-8
Abstract
An efficient process for the synthesis of (R)-N-t-Boc-4-piperidinylglycine 8a, an unnatural amino acid, via enantioselective rhodium-catalyzed hydroge nation of the Cbz-enamide 5a is described. Subsequent deprotection of 8a af fords unprotected (R)-4-piperidinylglycine 9 in good yield. (C) 2001 Elsevi er Science Ltd. All rights reserved.