Increased QT dispersion in hemodialysis patients improve after renal transplantation: A prospective controlled study

Increased QT dispersion (QTd), predicting patients with risk of malignant a rrhythmia, have recently been reported in hemodialysis patients (HDp). In t his prospective study, we aimed to investigate changes in QTd and signal av eraged-ECG (SAECG) in HDp after transplantation. Twenty-seven HDp (M/F:18/9 , mean age 30 +/-8 years) and 24 controls (M/F:14/10, mean age 33 +/-6 year s) were included. All QT parameters QTmax, Qtmin, and QTd) were increased i n HDp. QTmax and QTd started to decrease at the first month after transplan tation. Percentage change in QTd at the third month was significantly corre lated with percentage change in LV mass index (r=0.45, P=0.04), serum calci um (r=-0.47, P=0.02) and intact parathyroid hormone (r=0.68, P=0.01). In mu ltivariate regression analysis, only percent chance in LV mass index was re tained as significant. As for analysis of SAECG, 4 of the 23 (17%) HDp has abnormal late potentials which disappeared after transplantation. HDp with LV hypertrophy had higher filtered-QRS duration compared to patients withou t hypertrophy (110 +/- 12 vs. 97 +/- 11 msec, P=0.01). It was concluded tha t increased and presence of late potentials improved early after renal tran splantation. These changes were mainly associated with the regression of th e IV mass.