Malignant mesothelioma of the male genital tract: report of two cases

Two patients with urogenital mesothelioma are presented. The first patient had a malignant epithelial mesothelioma involving the scrotum and the perit oneal cavity. This patient was treated by extensive surgery and intraperito neal perioperative chemotherapy; he is well and alive 62 months after diagn osis. The second patient had an aggressive malignant epithelioid mesothelio ma of the tunica vaginalis testis; he died 24 months after diagnosis, with locoregional and metastatic recurrent disease, in spite of surgical and sys temic chemotherapy treatment. Calretinin immunostains were positive in the first case and negative in the second. Eighty-eight previously published ca ses of malignant mesothelioma of the tunica vaginalis testis were found in a review of the literature to date. Mesothelioma of the tunica vaginalis te stis usually presents as a scrotal mass, thus requiring urologist skills fo r first line treatment. A multidisciplinary approach is advised when dealin g with the malignant form, considering its aggressive natural history. (C) 2001 Elsevier Science Inc. All rights reserved.