Allergy and childhood epilepsy: a close relationship?

Objectives - The possibility that certain foods or allergens may induce con vulsions has already been reported in the literature. None of the relevant studies has, however, shown a close correlation between allergy and epileps y, most reports being anecdotal and open to various causal hypotheses. The case-control study reported here was undertaken to test the hypothesis that epilepsy is linked to allergy. Material and Methods Seventy-two epileptic children and a group of 202 controls in the same age bracket were investiga ted for allergy together with their immediate families. Results - The Study revealed significantly higher rates of eczema in the mothers and rhinitis in the siblings of the patients studied as well as generally higher inciden ce of allergic pathologies in both of these groups with respect to the rele vant controls. A significantly higher incidence of allergy to cow's milk an d asthma was also documented in the epileptic children with respect to the control group. Prick tests gave a significantly, higher rate of positive re sults for cow's milk proteins in the cases examined with respect to the con trols. The total serum IgE of a random sample of cases and controls showed no difference in mean values. Conclusion - The study appears to bear out th e hypothesis of a higher incidence of allergy in the children with epilepsy and their immediate families than in the controls and their families.