Familial carpal tunnel syndrome: a report of a Finnish family

The existence of familial carpal tunnel syndrome (FCTS) as a separate auton omic entity has been discussed during the last few years. In order to contr ibute with more data to the literature, we report here the results of clini cal, electro physiological, pathological and radiological studies performed in 5 patients belonging to the same Finnish pedigree. The disease appeared usually before the second decade with numbness and pain on the I-III digit s. Iri most patients symptoms were unilateral but within 2 years they becam e bilateral. In all patients typical electrophysiological features of media n nerve entrapment have been recorded. X-rays of the wrist showed narrow ca rpal tunnel in all patients. In all patients the possibility of having HNPP as well as familial amyloidosis has been excluded by molecular genetic and pathological studies. All patients underwent surgery and at postoperative stage symptoms were relieved or completely disappeared. Our study supports the theory that FCTS exists as a separate autonomic entity, therefore it is important in front of a sporadic case to investigate the family occurrence of CTS.