Effects of losartan in patients with a systemically functioning morphologic right ventricle after atrial repair of transposition of the great arteries

Authors
Lester, SJ McElhinney, DB Viloria, E Reddy, GP Ryan, E Tworetzky, W Schiller, NB Foster, E
Citation
Sj. Lester et al., Effects of losartan in patients with a systemically functioning morphologic right ventricle after atrial repair of transposition of the great arteries, AM J CARD, 88(11), 2001, pp. 1314
Categorie Soggetti
Cardiovascular & Respiratory Systems","Cardiovascular & Hematology Research
Journal title
AMERICAN JOURNAL OF CARDIOLOGY
ISSN journal
00029149 → ACNP
Volume
88
Issue
11
Year of publication
2001
Database
ISI
SICI code
0002-9149(200112)88:11<1314:EOLIPW>2.0.ZU;2-Z
Abstract
The effect of losartan, an angiotensin II receptor antagonist, was evaluate d in 7 patients with transposition of the great arteries. This study showed a trend toward improvement in ejection phase indexes of the systemic ventr icle, significant reduction in the regurgitant orifice area and regurgitant volume of the systemic atrioventricular valve, and significant improvement in exercise time.