Predictive value of a 1-day, 1-eye trial on the 1-month ocular hypotensiveresponse of latanoprost 0.005%

- PURPOSE: To determine if a 1-day, 1-eye trial of latanoprost 0.005% was p redictive of the 1-month intraocular pressure response in patients with unc ontrolled open-angle glaucoma on maximally tolerated medical therapy withou t latanoprost. - METHODS: One eye of 39 consecutive patients was enrolled in prospective t rial of latanoprost 0.005%. An investigator masked to treatment eye and int raocular pressure result measured intraocular pressure at 1 day and 1 month after treatment. The diagnostic precision of the 1,day, 1-eye trial for th e 1-month result was deter, mined at a 10%, 20%, and 30% reduction from bas eline intraocular pressure. - RESULTS: Treatment produced a mean +/- SD (range) decrease in intraocular pressure from 20.9 +/- 4.6 (14 to 35) mm. Hg to 16.6 +/- 3.6 (9 to 26) mm Hg at 24 hours (P < .0001, paired t test). This reduction in intraocular pr essure was similar at I month with mean +/- SD (range) intraocular pressure of 16.1 +/- 3.1 (9 to 22) mm Hg (P < .0001, paired t test). The accuracy o f the I day, 1-eye trial for the 1-month response at a 10%, 20%, and 30% re duction of intraocular pressure from baseline intraocular pressure was 96% (chi square = 29.5, P < .001), 74% (chi square = 8.4, P = .004), and 80% (c hi square = 10.2, P = .001), respectively. - CONCLUSION: A 1-day, I-eye trial of latanoprost 0.005% is predictive of t he I-month intraocular pressure response in patients with uncontrolled open -angle glaucoma. (C) 2001 by Elsevier Science Inc. All rights reserved.