In this paper, we describe the design of a new versatile and reversible DNA
sensor. The system is based on biotin grafting-units, covalently linked to
a polypyrrole matrix, able to anchor large biomolecules, thanks to biotin/
avidin affinity. These grafting-units can be regenerated after the "denatur
ation" of the biotin/avidin link allowing to reuse the matrix for the immob
ilisation of an other assembly and then the possibility to generate a new s
ensor. (C) 2001 Elsevier Science BN. All rights reserved.