Mammary carcinoma arising in microglandular adenosis: a case report

Microglandular adenosis is an uncommon benign breast entity considered as a variant form of adenosis. The diagnosis is frequently made by the patholog ist as it is often clinically asymptomatic. Carcinoma arising in microgland ular adenosis is very uncommon. We report a case of carcinoma arising in mi croglandular adenosis in a 54-year-old woman, The immunohistochemical profi le, especially S100 protein expression and absence of epithelial membrane a ntigen, was useful to recognize the microglandular adenosis and the carcino ma of alveolar architecture, while invasion was suggested by the basement m embrane disruption highlighted with anti-collagen IV immunostaining. The go od prognosis of carcinoma associated with microglandular adenosis points ou t the importance of distinguishing this lesion from other breast carcinomas .