Conventional carbon dioxide application does not reduce cerebral or myocardial damage in open heart surgery

Background. Open heart surgery is associated with a significant risk of cer ebral and myocardial dysfunction, which is attributed in part to air emboli sm from incompletely deaired cardiac chambers. To evaluate the impact of ca rbon dioxide (CO2) insufflation to the thoracic cavity, a prospective rando mized study was designed. Methods. A total of 62 elective patients were randomly assigned to CO2 insu fflation (group I, n = 31) or control (group II, n = 31). According to the Parsonnet risk score, 16 patients in group I (52%) and 10 patients in group II (32%) were categorized as being at either high risk or extremely high r isk. Results. In group II, perioperative mortality was 16.1% (5 patients); in gr oup I, 1 patient died (ns). Creatine kinase MB isoenzyme, as a marker of my ocardial damage, was more elevated in group I after surgery (38.0 +/- 4.1 v s 28.0 +/- 2.1, p = 0.02). Neurocognitive test scores did not reveal signif icant postoperative differences between groups. Conclusions. Although mortality was lower with CO2 insufflation, no benefit could be demonstrated for markers of cardiac ischemic damage or neurocogni tive outcome in this high-risk population. As CO2 concentrations in the tho racic cavity did not necessarily reach anticipated levels, our method of ap plication is in question. (C) 2001 by The Society of Thoracic Surgeons.