Over an 8-year period, we performed 93 lower extremity bypasses using compl
ex autologous conduits, which included (1) contralateral greater saphenous
vein (GSV), (2) composite GSV, (3) superficial femoral vein, (4) lesser sap
henous vein, (5) cephalic or basilic veins, and (6) composite-sequential (P
TFE and vein) grafts. These grafts represented 16% of all infrainguinal byp
asses during this period, and all grafts were performed to treat limb-threa
tening ischemia. Survival, patency, and limb salvage were examined by the l
ife-table method. Primary graft patency was 46 and 38% at 3 and 5 years. As
sisted-primary patency was 62 and 59%, and secondary graft patency rates we
re 68 and 64% at 3 and 5 years. Twenty-nine bypasses (31%) required revisio
n to restore or maintain patency. The 3-year limb salvage rate was signific
antly better when revision was performed for graft stenosis than for graft
thrombosis (90% vs. 46%, p <0.05). Overall limb salvage rate was 73% at 5 y
ears. The mortality rate was 5.4% and the 5-year survival was 51%. Complex
autologous tibial bypasses provided acceptable long-term limb salvage in pa
tients with severe ischemia and inadequate ipsilateral GSV. The increased o
perating time and complexity required did not produce prohibitive operative
risks. Postoperative graft surveillance in these complex vein bypasses all
owed revision in many cases before graft occlusion occurred and significant
ly improved long-term limb salvage.