Neonatal vein thrombosis in a heterozygous carrier of both factor V Leidenand prothrombin mutations

We report a case of renal vein thrombosis, treated with heparin and thrombo lytic therapy, in a patient who was heterozygous for both factor V Leiden a nd prothrombin mutations. Case report. - A full-term infant was treated with heparin and fibrinolytic s at the fourth day of life because of renal vein thrombosis. inferior vena cava thrombosis and adrenal hemorrhage. After four days of treatment, the repermeabilization was complete but a renal atrophy developed. The investig ation for congenital coagulation disorders revealed a heterozygous mutation for both factor V Leiden and prothrombin. Conclusion. - Search for inborn blood coagulation disorders should be syste matic in the newborn infant with venous thrombosis because of the risk of r ecurrence, even in the presence of a known acquired risk factor. The thromb olytic treatment improves the prognosis. (C) 2001 Editions scientifiques, e t medicales Elsevier SAS.