Recently developed synthetic methodology has been exploited for the prepara
tion of an assortment of alpha,alpha'-disubstituted disulfides including al
l three linkage isomeric types of alpha,alpha'-diester dimethyl disulfides.
Two of the diesters are very powerful antifungal agents against Aspergillu
s niger and Aspergillus flavus. An alpha -ester alpha'-sulfone disulfide is
the most powerful fungitoxin developed by this ongoing research effort.