Palladium-catalysed cross coupling of arylboronic acids with 2-chloro-1,4-naphthoquinones: the synthesis of 2-aryl- and 2,3-bisaryl-1,4-naphthoquinones
Wm. Best et al., Palladium-catalysed cross coupling of arylboronic acids with 2-chloro-1,4-naphthoquinones: the synthesis of 2-aryl- and 2,3-bisaryl-1,4-naphthoquinones, AUST J CHEM, 54(6), 2001, pp. 401-404
2-Chloro-1,4-naphthoquinones underwent palladium-catalysed cross coupling r
eactions with arylboronic acids to give the corresponding 2-aryl-1,4-naphth
oquinones. Similarly, 2,3-dichloro-1,4-naphthoquinone underwent efficient c
ross coupling reactions with arylboronic acids to give mono or bis adducts.
The required 2-chloro-1,4-naphthoquinones were conveniently prepared from
the corresponding 2-hydroxy-1,4-naphthoquinones by treatment with oxalyl ch
loride.