Destrin is a 19 kDa actin-depolymerizing protein of the ADF-cofilin family.
Destrin was digested with trypsin to a structurally stable 9.2 kDa fragmen
t that contains the actin-binding sequence. The purified 9.2 kDa fragment h
as an actin filament stabilizing activity, rather than an actin filament de
polymerizing activity. The deleted region is probably essential for the act
in filament depolymerizing activity of intact destrin. Surprisingly, the 9.
2 kDa fragment also has an assembly-promoting activity in the absence of AT
P.