Protective effect of ajoene on acetaminophen-induced hepatic injury in mice

Authors
Hattori, A Yamada, N Nishikawa, T Fukuda, H Fujino, T
Citation
A. Hattori et al., Protective effect of ajoene on acetaminophen-induced hepatic injury in mice, BIOS BIOT B, 65(11), 2001, pp. 2555-2557
Citations number
22
Categorie Soggetti
Agricultural Chemistry","Biochemistry & Biophysics
Journal title
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
ISSN journal
09168451 → ACNP
Volume
65
Issue
11
Year of publication
2001
Pages
2555 - 2557
Database
ISI
SICI code
0916-8451(200111)65:11<2555:PEOAOA>2.0.ZU;2-R
Abstract
Ajoene, a garlic-derived sulfur-containing compound, exhibited a hepatoprot ective effect against acetaminophen-induced liver injury in mice. A pretrea tment with ajoene suppressed the rise in serum glutamic-pyruvic transaminas e activity and the reduction in the hepatic reduced glutathione level. Thes e effects of ajoene were observed dose-dependently (20-100 mg/kg). The pret reatment by ajoene also suppressed the decrease in hepatic protein thiol co ntent resulting from acetaminophen administration.