September 2001: 51-year-old man with seizures since childhood - Diagnosis - Ganglioglioma with neurofibrillary tangles.

The September 2001 COM. A 51 year old man with refractory seizures presente d with a recent seizure while at work but no other neurologic deficit. Imag ing studies demonstrated a solid and cystic lesion of the right temporal lo be. Microscopic and immunohistochemical studies demonstrated an atypical ga nglioglioma due to the presence of neurofibrillary tangles within the neopl astic ganglion cell component. This is the fifth case reported in the liter ature. Neoplastic ganglion cells and neurofibrillary tangles are discussed both separately and as integral components of this rare tumor.