Short wavelength automated perimetry in age related maculopathy

Background/aims-Previous studies reported the predictive value of the short wavelength sensitive (SWS) cone mediated sensitivity for visual outcome in age related macular degeneration. In this study SWS sensitivity was measur ed by commercially available blue on yellow perimetry in patients with non- exudative age related maculopathy (ARM) and compared with the presence of m orphological risk factors and the status of the fellow eye. Methods-In a prospective cross sectional study, 126 patients (57 males, 69 females, mean age 71 (SD 6) years) with ARM (visual acuity > 20/50) were te sted. Central visual fields (blue on yellow) were obtained with a conventio nal perimeter. Fundus slides were graded by two independent observers for s oft drusen and presence of focal hyperpigmentation. Results-Mean sensitivity and standard deviation of all patients exhibited a significant reduction with age. Patients with soft drusen had significantl y lower sensitivity than those without, whereas there were no differences i n visual acuity (log MAR). Sensitivity was also reduced in those eyes with fellow eyes having a sight threatening complication of age related macular degeneration (AMD). Eyes with focal hyperpigmentation compared with those w ithout had no loss of sensitivity, but did have a significant decrease in t he central part of the field compared with the more eccentric. Conclusion-SWS sensitivity loss is associated with common risk factors for progression to AMD. Short wavelength automated perimetry is moderately rapi d and readily available. It may serve as a tool in future ARM trials.