An efficient enantioselective preparation of (S,S)-1,2-bis(1-hydroxyalkyl)benzene

Authors
Asami, M Wada, M Furuya, S
Citation
M. Asami et al., An efficient enantioselective preparation of (S,S)-1,2-bis(1-hydroxyalkyl)benzene, CHEM LETT, (11), 2001, pp. 1110-1111
Citations number
20
Categorie Soggetti
Chemistry
Journal title
CHEMISTRY LETTERS
ISSN journal
03667022 → ACNP
Issue
11
Year of publication
2001
Pages
1110 - 1111
Database
ISI
SICI code
0366-7022(20011105):11<1110:AEEPO(>2.0.ZU;2-Q
Abstract
(S,S)-1,2-Bis(I-hydroxyalkyl)benzenes were obtained in >99% ee's with high diastereoselectivity by the enantioselective addition of dialkylzinc to (S) -2-[1-(4-methoxybenzyloxy)alkyl]benzaldehyde (86% ee) in the presence of a catalytic amount of (S)-2-(4-methylpiperazin-1-ylmethyl)indoline.