Role of disulfide bridges in the hairpin fold of androctonin. Structure-activity relationships.

Authors
Mandard, N Labbe, H Da Silva, P Hetru, C Landon, C Vovelle, F
Citation
N. Mandard et al., Role of disulfide bridges in the hairpin fold of androctonin. Structure-activity relationships., CR AC S IIC, 4(10), 2001, pp. 735-738
Citations number
7
Categorie Soggetti
Chemistry
Journal title
COMPTES RENDUS DE L ACADEMIE DES SCIENCES SERIE II FASCICULE C-CHIMIE
ISSN journal
13871609 → ACNP
Volume
4
Issue
10
Year of publication
2001
Pages
735 - 738
Database
ISI
SICI code
1387-1609(200110)4:10<735:RODBIT>2.0.ZU;2-A
Abstract
Androctonin is a 25-residue antibacterial peptide extracted from the hemoly mph of the scorpion Androctonus australis. In order to understand the struc tural requirements for hairpin fold and for interactions with the bacterial membrane, we have analysed the chemical shifts and the noes of three synth etic androctonin mutants for which the disulfide bridges were selectively r emoved. (C) 2001 Academie des sciences/Editions scientifiques et medicales Elsevier SAS.