In the first half of the twentieth century epidemiologic evidence linked el
evated incidences of pulmonary fibrosis and cancer with inhalation of chrys
otile and crocidolite asbestos, a family of naturally occurring inorganic f
ibrous materials. As the serpentine and amphibole forms of asbestos were ph
ased out, synthetic vitreous fibers (SVFs; fiber glass, mineral wool, and r
efractory fiber) became increasingly utilized, and concerns were raised tha
t they too might cause adverse health effects. Extensive toxicological rese
arch on SVFs has demonstrated that their pulmonary effects are directly rel
ated to fiber dose in the lung over time. This is the result of deposition
(thin fibers deposit in the lower lung more efficiently than thick fibers)
and lung-persistence ("biopersistence" is directly related to fiber length
and inversely related to dissolution and fragmentation rates). In rat inhal
ation studies, asbestos was determined to be 7- to 10-fold more biopersiste
nt in the lung than SVFs. Other than its effect on biopersistence, fiber co
mposition did not appear to play a direct role in the biological activity o
f SVFs. Recently, the utilization of man-made organic fibers (MMOFs) (also
referred to by some as synthetic organic fibers) has increased rapidly for
a variety of applications. In contrast to SVFs, research on the potential p
ulmonary effects of MMOFs is relatively limited, because traditionally MMOF
s were manufactured in diameters too thick to be respirable (inhalable into
the lower lung). However, new developments in the MMOF industry have resul
ted in the production of increasingly fine-diameter fibers for special appl
ications, and certain post-manufacturing processes (e.g., chopping) generat
e respirable-sized MMOF dust. Until the mid-1990s, there was no consistent
evidence of human health affects attributed to occupational exposure to MMO
Fs. Very recently, however, a unique form of interstitial lung disease has
been reported in nylon flock workers in three different plants, and respira
ble-sized nylon shreds (including fibers) were identified in workplace air
samples. Whether nylon dust or other occupational exposures are responsible
for the development of lung disease in these workers remains to be determi
ned. It is also unknown whether the biological mechanisms that determine th
e respirability and toxicity of SVFs apply to MMOFs. Thus, it is appropriat
e and timely to review the current data regarding MMOF workplace exposure a
nd pulmonary health effects, including the database on epidemiological, exp
osure assessment, and toxicology studies.