Biocatalytic synthesis of hydroxylated natural products using aldolases and related enzymes

Synthetic building blocks bearing hydroxylated chiral centers are important targets for biocatalysis. Many C-C bond forming enzymes have recently been investigated for new applications and new strategies towards the synthesis of natural products and related oxygenated compounds. Several old catalyst s have been studied to increase our functional knowledge of natural aldolas e-type enzymes, and new mutated catalysts or catalytic antibodies have been tested for their synthetic utility.