Wd. Fessner et V. Helaine, Biocatalytic synthesis of hydroxylated natural products using aldolases and related enzymes, CURR OPIN B, 12(6), 2001, pp. 574-586
Synthetic building blocks bearing hydroxylated chiral centers are important
targets for biocatalysis. Many C-C bond forming enzymes have recently been
investigated for new applications and new strategies towards the synthesis
of natural products and related oxygenated compounds. Several old catalyst
s have been studied to increase our functional knowledge of natural aldolas
e-type enzymes, and new mutated catalysts or catalytic antibodies have been
tested for their synthetic utility.