In vivo drug target discovery: identifying the best targets from the genome

Authors
Walke, DW Han, CS Shaw, J Wann, E Zambrowicz, B Sands, A
Citation
Dw. Walke et al., In vivo drug target discovery: identifying the best targets from the genome, CURR OPIN B, 12(6), 2001, pp. 626-631
Citations number
24
Categorie Soggetti
Microbiology
Journal title
CURRENT OPINION IN BIOTECHNOLOGY
ISSN journal
09581669 → ACNP
Volume
12
Issue
6
Year of publication
2001
Pages
626 - 631
Database
ISI
SICI code
0958-1669(200112)12:6<626:IVDTDI>2.0.ZU;2-O
Abstract
A vast number of genes of unknown function threaten to clog drug discovery pipelines. To develop therapeutic products from novel genomic targets, it w ill be necessary to correlate biology with gene sequence information. Indus trialized mouse reverse genetics is being used to determine gene function i n the context of mammalian physiology and to identify the best targets for drug development.