Custom DNA-binding proteins come of age: polydactyl zinc-finger proteins

Authors
Segal, DJ Barbas, CF
Citation
Dj. Segal et Cf. Barbas, Custom DNA-binding proteins come of age: polydactyl zinc-finger proteins, CURR OPIN B, 12(6), 2001, pp. 632-637
Citations number
43
Categorie Soggetti
Microbiology
Journal title
CURRENT OPINION IN BIOTECHNOLOGY
ISSN journal
09581669 → ACNP
Volume
12
Issue
6
Year of publication
2001
Pages
632 - 637
Database
ISI
SICI code
0958-1669(200112)12:6<632:CDPCOA>2.0.ZU;2-Q
Abstract
Artificial transcription factors based on modified zinc-finger DNA-binding domains have been shown to activate or repress the transcription of endogen ous genes in multiple organisms. Advances in both the construction of novel zinc-finger proteins and our understanding of the characteristics of a pro ductive regulatory site have fueled these achievements.