Computational protein design

The field of computational protein design is reaching its adolescence. Prot ein design algorithms have been applied to design or engineer proteins that fold, fold faster, catalyze, catalyze faster, signal, and adopt preferred conformational states. Further developments of scoring functions, sampling strategies, and optimization methods will expand the range of applicability of computational protein design to larger and more varied systems, with gr eater incidence of success. Developments in this field are beginning to hav e significant impact on biotechnology and chemical biology.