Was the historic contribution of Spain to the Mexican gene pool partially responsible for the higher prevalence of type 2 diabetes in Mexican-origin populations? The Spanish Insulin Resistance Study Group, the San Antonio Heart Study, and the Mexico City Diabetes Study

Citation
C. Lorenzo et al., Was the historic contribution of Spain to the Mexican gene pool partially responsible for the higher prevalence of type 2 diabetes in Mexican-origin populations? The Spanish Insulin Resistance Study Group, the San Antonio Heart Study, and the Mexico City Diabetes Study, DIABET CARE, 24(12), 2001, pp. 2059-2064
Citations number
24
Categorie Soggetti
Endocrynology, Metabolism & Nutrition","Endocrinology, Nutrition & Metabolism
Journal title
DIABETES CARE
ISSN journal
01495992 → ACNP
Volume
24
Issue
12
Year of publication
2001
Pages
2059 - 2064
Database
ISI
SICI code
0149-5992(200112)24:12<2059:WTHCOS>2.0.ZU;2-7
Abstract
OBJECTIVE - Mexican-American populations in San Antonio, Texas (SA-MA) and Mexico have a higher prevalence of type 2 diabetes than non-Hispanic whites in San Antonio (SA-NHW). However, the higher prevalence of type 2 diabetes in Mexican-origin populations might be related, in part, not to Native Ame rican genetic admixture but to Spanish genetic admixture. RESEARCH DESIGN AND METHODS - Four population-based epidemiological surveys conducted with Mexican-origin and European-origin samples provided data re levant to this question. in all four surveys, type 2 diabetes was defined a s fasting plasma glucose greater than or equal to7.0 mmol/l or 2-h glucose greater than or equal to 11.1 mmol/l or use of antidiabetic agents. RESULTS - A comparison of the two Mexican-origin populations showed that th e age- and sex-adjusted prevalence of type 2 diabetes was lower in Mexico t han in SA-MA (15.1 vs. 17.9%, P = 0.032). Between the two European-origin p opulations, the prevalence of type 2 diabetes was lower in SA-NHW than in S pain (6.2 vs. 9.1%, P < 0.0001), but differences were attenuated by adjustm ent BMI or after stratification by education. In logistic regression analys es, type 2 diabetes was associated with Mexican ethnic origin after adjusti ng for age, education, BMI, and waist-to-hip ratio. CONCLUSIONS - The prevalence of type 2 diabetes in Spain was intermediate b etween that in Mexican-origin populations and SA-NHW. Although the higher d egree of Native American admixture is a major contributor to the higher rat es of type 2 diabetes, we cannot completely rule out a partial contribution of Spanish admixture to diabetes susceptibility among Mexican-origin popul ations.