CCL- and PLE-catalyzed reverse enantiomeric separation of various (+/-)-2-thienylicarbinols

(+/-)-2-Thienylcarbinols and their O-acetyl derivatives were resolved in re verse separation by CCL and PLE catalysed hydrolysis to afford optically ac tive 2-thienylcarbinols in 35%-99% e.e. that are valuable chiral building b locks, in particular in the synthesis of pheromones and some alkoloid type natural products. Absolute configurations were determined by the correlatio n of specific rotation values with the literature and by transforming into the corresponding secondary alcohols via reductive desulfurization by Ra-Ni .