Urokinase plasminogen activator and its inhibitor, PAI-1, in association with progression-free survival in early stage endometrial cancer

Components of the urokinase plasminogen activator (u-PA) system are involve d in the metastatic process, and have accordingly been associated with clin ical outcome in a variety of malignant tumours. We investigated the prognos tic importance of u-PA and plasminogen activator inhibitor type 1 (PAI-1) i n endometrial cancer, analysed with luminometric immunoassay (LIA) and enzy me-linked immunosorbent assay (ELISA), respectively. Two different cut-off levels were used: the median and the 80th percentile-the latter because of the low progression rate for patients with early stage (I-II) endometrial c ancer. After a median follow-up time of 6.8 years, univariate analysis of p atients with stage I-II disease (n = 188) showed that high u-PA and high PA I-1 content was associated with a shorter progression-free survival (PFS), but at different cut-off levels, uPA at the median (P = 0.003), and PAI-1 a t the 80th percentile (P < 0.001). Among the other factors, DNA ploidy stat us was most strongly correlated to PFS, followed by age (continuous), Inter national Federation of Gynaecology and Obstetrics (FIGO) grade of different iation, S-phase fraction and progesterone receptor (PgR) status. Bivariate analyses, including ploidy and one of the factors u-PA or PAI-1, showed tha t both add significant prognostic information. We conclude that u-PA and PA M are promising prognostic factors in early stage endometrial cancer. (C) 2 001 Elsevier Science Ltd. All rights reserved.