Ductal carcinoma in situ of the breast results of conservative and radicaltreatments in 716 patients

Citation
B. Cutuli et al., Ductal carcinoma in situ of the breast results of conservative and radicaltreatments in 716 patients, EUR J CANC, 37(18), 2001, pp. 2365-2372
Citations number
34
Categorie Soggetti
Oncology,"Onconogenesis & Cancer Research
Journal title
EUROPEAN JOURNAL OF CANCER
ISSN journal
09598049 → ACNP
Volume
37
Issue
18
Year of publication
2001
Pages
2365 - 2372
Database
ISI
SICI code
0959-8049(200112)37:18<2365:DCISOT>2.0.ZU;2-J
Abstract
Until now, less than 5% of the patients with breast ductal carcinoma in sit u (DCIS) have been enrolled in clinical trials. Consequently, we have analy sed the results of 'current practice' among 716 women treated in eight Fren ch Cancer Centres from 1985 to 1992: 441 cases (61.6%) corresponded to impa lpable lesions, 92 had a clinical size of less than or equal to 2 cm and 70 from 2 to 5 cm; in 113 cases, the size was unspecified. Median age was 53. 2 years (range: 21-87 years). 145 patients underwent mastectomy (RS) and 57 1 conservative surgery (CS) without (136) or with (435) radiotherapy (CS RT). The mean histological tumour sizes in these three groups were 25.6, 8. 2, 14.8 min, respectively (P <0.0001). After a 91-month median follow-up, l ocal recurrence (LR) rates were 2.1, 30.1 and 13.8% in the RS, CS and CS RT groups, respectively (P = 0.001); LR were invasive in 59 and 60% in the CS and CS + RT groups, respectively. In these groups, the 8-year LR rates w ere 31.3 and 13.9%, respectively (P = 0.0001). Nodal recurrence occurred in 3.7 and 1.8% in the CS and CS + RT groups. Metastases rates were 1.4, 4.4 and 1.4% in the RS, CS and CS + RT groups. Among the 60 cases of invasive L R, in CS and CS + RT groups 19% developed metastases. After multivariate an alysis, we did not identify any significant LR risk factor in the CS group, whereas young age (< 40years) and incomplete excision were significant in the CS + RT group (P = 0.012 and P = 0.02, respectively). (C) 2001 Elsevier Science Ltd. All rights reserved.