Noncompliance among a group of women using a novel method of contraception

Objective: To compare the incidence of noncompliance measured objectively b y a home use fertility monitor with the traditional self-reported incidence of compliance in a study of a new method of contraception. Design: Prospective cohort study. Setting: A large fan-Lily planning clinic in Edinburgh. Patient(s): Thirty-two healthy women who took part in a trial assessing the efficacy of a novel method of contraception involving accurately timed adm inistration of a single dose of mifepristone. Intervention(s): Mifepristone was administered orally and a blood sample wa s collected on the same day. Main Outcome Measure(s): Percentage of missed tests detected by the monitor against the self-reported percentage during the critical period. Result(s): Women failed to perform 24.2% (95% confidence interval, 16.5-31. 5) of the tests in the 162 cycles analyzed. They missed tests at an absolut ely vital time for contraceptive efficacy in 42% of cycles according to the monitor while admitting to missing tests in 14.8%. Poor compliance was ass ociated with younger women, those who discontinued the study before complet ion, and cycles in which women were not relying on the contraceptive method , Conclusion(s): The use of microelectronic monitoring systems may improve Ou r understanding of the extent of patient noncompliance, providing objective information that no other monitoring technique can produce. This understan ding provides the opportunity to make the optimum use of potentially effect ive treatments while validating research evidence. (Fertil Steril (R) 2001; 76:1196-1201. (C) 2001 by American Society for Reproductive Medicine.).