Recurrence of OTT-MAL fusion in t(1;22) of infant AML-M7

Authors
Mercher, T Coniat, MB Khac, FN Ballerini, P Mauchauffe, M Bui, H Pellegrino, B Radford, I Valensi, F Mugneret, F Dastugue, N Bernard, OA Berger, R
Citation
T. Mercher et al., Recurrence of OTT-MAL fusion in t(1;22) of infant AML-M7, GENE CHROM, 33(1), 2002, pp. 22-28
Citations number
15
Categorie Soggetti
Onconogenesis & Cancer Research
Journal title
GENES CHROMOSOMES & CANCER
ISSN journal
10452257 → ACNP
Volume
33
Issue
1
Year of publication
2002
Pages
22 - 28
Database
ISI
SICI code
1045-2257(200201)33:1<22:ROOFIT>2.0.ZU;2-0
Abstract
Translocation t(1;22)(p13;q13) is associated with a peculiar subtype of acu te megakaryocytic leukemia (M7) occurring in infants. We have recently char acterized a fusion gene, OTT-MAL, resulting from this translocation. We now report three additional cases and show that this gene fusion is present in all five t(1;22) cases studied to date. Nucleotide sequence analysis of tw o translocation breakpoints suggests a nonhomologous end joining mechanism in the genesis of this translocation and reveals a noncanonical topoisomera se II-like consensus sequence within the OTT gene. FISH and PCR techniques described in this work are useful for identifying t(1;22) associated with M 7. (C) 2002 Wiley-Liss, Inc.