The ethical conduct of studies involving controlled human exposure to environmental pollutants

In recent years, the concern for human research subject protection has incr eased markedly in the United States. The nature of research subject partici pation in controlled-exposure environmental health research is such that th e individual subject bears the risk of participation, while the benefits of such research accrue to society. Therefore, particular attention must be p aid when designing studies to protect the health and safety of human resear ch subject. This paper outlines principles for the appropriate selection of pollutants to which humans can be exposed, and the principles that should be used to protect the health and safety of human research subject.