N. Mohan et al., Topical ciprofloxacin-dexamethasone combination therapy after cataract surgery - Randomized controlled clinical trial, J CAT REF S, 27(12), 2001, pp. 1975-1978
Purpose: To determine the efficacy of a combination of ciprofloxacin 0.3% a
nd dexamethasone 0.1% eyedrops in controlling immediate inflammation after
cataract surgery.
Setting: Dr. Rajendra Prasad Centre for Ophthalmic Sciences and Department
of Pharmacology, All India Institute of Medical Sciences, New Delhi, India.
Methods: This randomized controlled clinical trial comprised 61 patients, 3
1 of whom were treated with a combined ciprofloxacin-dexamethasone suspensi
on (study group) and 30, with a standard formulation of betamethasone and n
eomycin eyedrops (control group). One and 7 days postoperatively, pain, lid
edema, lacrimation, conjunctival congestion, aqueous flare and cells, and
side effects were noted. A conjunctival swab for bacteria and a fungus cult
ure were sent for evaluation 7 days postoperatively.
Results: At 7 days, there was no statistically significant difference betwe
en groups in lid edema, conjunctival congestion, anterior segment inflammat
ion, lacrimation, or pain. Two patients in the ciprofloxacin-dexamethasone
group noted white deposits in and around the eye that resolved after the do
se was reduced to 4 times a day. No patient reported or developed an allerg
ic reaction to either drug combination.
Conclusion: A ciprofloxacin-dexamethasone combination was effective in cont
rolling inflammation after cataract surgery. (C) 2001 ASCRS and ESCPS.