Topical ciprofloxacin-dexamethasone combination therapy after cataract surgery - Randomized controlled clinical trial

Citation
N. Mohan et al., Topical ciprofloxacin-dexamethasone combination therapy after cataract surgery - Randomized controlled clinical trial, J CAT REF S, 27(12), 2001, pp. 1975-1978
Citations number
10
Categorie Soggetti
Optalmology
Journal title
JOURNAL OF CATARACT AND REFRACTIVE SURGERY
ISSN journal
08863350 → ACNP
Volume
27
Issue
12
Year of publication
2001
Pages
1975 - 1978
Database
ISI
SICI code
0886-3350(200112)27:12<1975:TCCTAC>2.0.ZU;2-2
Abstract
Purpose: To determine the efficacy of a combination of ciprofloxacin 0.3% a nd dexamethasone 0.1% eyedrops in controlling immediate inflammation after cataract surgery. Setting: Dr. Rajendra Prasad Centre for Ophthalmic Sciences and Department of Pharmacology, All India Institute of Medical Sciences, New Delhi, India. Methods: This randomized controlled clinical trial comprised 61 patients, 3 1 of whom were treated with a combined ciprofloxacin-dexamethasone suspensi on (study group) and 30, with a standard formulation of betamethasone and n eomycin eyedrops (control group). One and 7 days postoperatively, pain, lid edema, lacrimation, conjunctival congestion, aqueous flare and cells, and side effects were noted. A conjunctival swab for bacteria and a fungus cult ure were sent for evaluation 7 days postoperatively. Results: At 7 days, there was no statistically significant difference betwe en groups in lid edema, conjunctival congestion, anterior segment inflammat ion, lacrimation, or pain. Two patients in the ciprofloxacin-dexamethasone group noted white deposits in and around the eye that resolved after the do se was reduced to 4 times a day. No patient reported or developed an allerg ic reaction to either drug combination. Conclusion: A ciprofloxacin-dexamethasone combination was effective in cont rolling inflammation after cataract surgery. (C) 2001 ASCRS and ESCPS.