Treatment of multiple miliary osteoma cutis of the face with local application of tretinoin (all-trans-retinoic acid): a case report and review of the literature
Ad. Cohen et al., Treatment of multiple miliary osteoma cutis of the face with local application of tretinoin (all-trans-retinoic acid): a case report and review of the literature, J DERM TR, 12(3), 2001, pp. 171-173
BACKGROUND: Multiple miliary osteoma cutis of the face represents primary e
xtra-skeletal bone formation that arises within the slain of the face.
METHODS: A 60-year-old woman with multiple miliary osteoma cutis of the fac
e was treated by application of 0.05% tretinoin (all-trans-retinoic acid) c
ream nightly.
RESULTS: After 3 months of therapy there were fewer papules and a decrease
in size of remaining lesions. In a literature search, it was found that loc
al application of tretinoin was successful and achieved a decrease in the n
umber of papules over the face in all patients with multiple miliary osteom
a cutis of the face; however, the length of time to achieve response varied
from a few weeks to 6 months.
CONCLUSION: It is suggested that local application of tretinoin cream shoul
d be considered in the therapy of multiple miliary osteoma cutis of the fac
e, particularly when the lesions are small and superficial.