G-protein beta(3) subunit C825T polymorphism: no association with risk forhypertension and obesity

Objective Several recent studies have indicated that a C825T polymorphism i n the gene encoding the G-protein beta (3) subunit is a significant risk fa ctor for hypertension and obesity. In this study, we tested whether this po lymorphism is associated with hypertension and obesity in white men. Design Population-based prospective cohort study. Methods We followed a cohort of 903 men, aged 42-61 years at baseline, for an average time of 4.2 years. Genotyping was performed by polymerase chain reaction. Results The genotype distribution was in Hardy-Weinberg equilibrium: 514 (5 7%) had the CC genotype, 49 (5%) had the TT genotype and 340 (38%) were het erozygous (T:C = 0.24:0.76). There was no statistically significant differe nce between the genotype groups in respect to baseline and end of follow-up risk for hypertension or obesity, systolic or diastolic blood pressure, or body mass index. Conclusion We conclude that the C825T polymorphism of the G-protein beta (3 ) subunit gene does not notably contribute to the development of hypertensi on or obesity, and is not a significant determinant for blood pressure and body mass index in white men. J Hypertens 19:2149-2155 (C) 2001 Lippincott Williams & Wilkins.